On April 27, the CDC [Centers for Disease Control and Prevention] changed its guidance to support broader use of testing not only for therapeutic purposes, but also for disease control. In the most recent guidance, released May 3, first priority goes to hospitalized patients, first responders with symptoms, and residents in congregate living contexts with symptoms. But there is now also a second priority category that includes asymptomatic individuals from groups experiencing disparate impacts of the disease and 'persons without symptoms who are prioritized by health departments or clinicians, for any reason, including but not limited to: public health monitoring, sentinel surveillance, or 'screening of other asymptomatic individuals according to state and local plans' (bold in original, italics added). The last phrase supports broad testing of contacts of COVID [coronavirus disease]-positive individuals and of essential workers, even when they have mild symptoms or none at all. This Supplement to our Roadmap to Pandemic Resilience offers guidance to help state and local governments develop TTSI (testing, tracing, and supported isolation) programs in support of such testing for purposes of disease control and suppression.